MARAN-iP - MRI of Tablet Dissolution in a USP-4 Compatible Cell

The development of today’s sophisticated drug therapies requires advanced drug formulations. It is important therefore to understand the mechanism of drug release behaviour, as this underpins the performance of many solid pharmaceutical dosage forms.

MARAN-iP combines a United States Pharmacopeia (USP-4) flow cell with Magnetic Resonance Imaging (MRI) and is used to image and understand complex pharmaceutical release processes.

Traditionally the use of MRI has been limited by high cost, complex operation and restricted access. MARAN-iP overcomes these limitations and provides for the first time easily accessible MRI capability within the dissolution laboratory that does not require expert operation.

MARAN is a trademark of Oxford Instruments Molecular Biotools Ltd.

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Typical tablet dissolution at time 0 hours	Typical tablet dissolution at time 8 hours

180cm x 74cm bench space for magnet, pump and computer.

Floor standing rack requires a 60cm x 80cm space and should be within 3m of the magnet.

Author	Journal	Reference	Title
Richardson J. C.; Bowtell R. W.; Mäder K.; Melia C. D.	Advanced Drug Delivery Reviews	2005, 57, 1191-1209	Pharmaceutical applications of magnetic resonance imaging (MRI)
Nott K. P.	European Journal of Pharmaceutics and Biopharmaceutics	2010, 74, 78-83	Magnetic resonance imaging of tablet dissolution
Strübing S.; Abboud T.; Contri R. V.; Metz H.; Mäder K.	European Journal of Pharmaceutics and Biopharmaceutics	2008, 69, 708-717	New insights on poly(vinyl acetate)-based coated floating tablets: Characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength
Metz H.; Mäder K.	International Journal of Pharmaceutics	2008, 364, 170-175	Benchtop-NMR and MRI-A new analytical tool in drug delivery research
Malaterre V.; Metz H.; Ogorka J.; Gurny R.; Loggia N.; Mäder K.	Journal of Controlled Release	2009, 133, 31-36	Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems
Strübing S.; Metz H.; Mäder K.	Journal of Controlled Release	2008, 126, 149-155	Characterization of poly(vinyl acetate) based floating matrix tablets