AFM for Biomaterials Research
AFM allows researchers to characterize the topography and mechanical properties of biomaterials. The AFM can accurately measure surface roughness and microstructure as a function of composition and processing variables. Biomaterials can also be inspected after in vitro testing or after explantation to assess changes in surface features. A wide range of AFM techniques can be applied to measure the stiffness, moduli and dissipation of biomaterials.
Measure surface morphology / surface roughness
Measure material properties (elastic modulus, loss modulus, hardness)
Measure surface changes during or after exposure to liquids (e.g. as related to biocompatibility)
Drug coatings (e.g. stents, catheters, etc.)
Anti-fouling coatings (e.g. catheters, implants, biosensors, etc.)
Tissue engineering and scaffold engineering
Crack Propagation in Bone Captured with In Situ Mechanical Testing During AFM
Bone, like all tissues, is built from structural elements starting at the nanometer scale. The generally complex and hierarchical arrangement of these basic elements into progressively larger structural features renders bone an anisotropic and anatomically distinct material adapted to specific loads and loading cases. Due to the hierarchical structure and complexity of bone, the uncovering of structure-function relationships, i.e. the origin of material properties such as strength, toughness, and fatigue resistance, is usually a non-trivial task. Atomic force microscopy (AFM) offers an approach to overcome some of these difficulties. Because AFM allows for imaging in ambient – even hydrated conditions – it is feasible to perform in situ micro-mechanical testing experiments while conducting imaging. Here we present first data obtained from a micro-tensile testing apparatus, demonstrating the power of this technique.
Asylum Research Image Gallery
This webinar provides an overview of the AFM’s powerful capabilities for polymers characterization.
Review of AFM measurements on single molecules and cells.
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